Targeting adhesion in fungal pathogen <i>Candida albicans</i>

Fungal infections with increasing resistance to conventional therapies are a growing concern. Candida albicans is major opportunistic yeast responsible for mucosal and invasive infections. Targeting the initial step of infection process (i.e., C. adhesion host cell) promising strategy. A wide variety molecules can interfere processes via an assortment mechanisms. Herein, we focus on how small disrupt biosynthesis fungal cell wall components membrane structure, prevent localization GPI-anchor proteins, inhibit production enzymes involved in adhesion, downregulate genes encoding adhesins competitively receptor interactions. As result, cells reduced, paving way new classes antifungal agents.